FK506 Itself Does Not Demonstrate Neurotoxicity in the Mouse Brain.
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منابع مشابه
Hemodynamic and Pathologic Characterization of the TASK-1−/− Mouse Does Not Demonstrate Pulmonary Hypertension
Introduction Pulmonary hypertension (PH) carries significant associated morbidity and mortality and the underlying molecular mechanisms of PH are not well understood. Loss-of-function mutations in TASK-1 potassium channels are associated with PH in humans. Although TASK-1 has been considered in the development of PH for over a decade, characterization of TASK-1 knockout mice has been limited to...
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The neurotrophic property of the immunosuppressant drug FK506 (tacrolimus) is believed to depend on the 12-kDa FK506-binding protein (FKBP-12). Here, we show that FK506 maintains its neurotrophic activity in primary hippocampal cell cultures from FKBP-12 knockout mice. In human neuroblastoma SH-SY5Y cells, the neurotrophic action of FK506 (10 pM to 10 nM) is completely prevented by the addition...
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of the human brain by heat loss from the upper respiratory tract. J Appl Physiol 87: 1609–1613, 1999. 17. Mariak Z, White MD, Lyson T, Lewko J. Tympanic temperature reflects intracranial temperature changes in humans. Pflugers Arch 446: 279–284, 2003. 18. Mellergard P, Nordstrom CH. Epidural temperature and possible intracerebral temperature gradients in man. Br J Neurosurg 4: 31–38, 1990. 19. ...
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ژورنال
عنوان ژورنال: ACTA HISTOCHEMICA ET CYTOCHEMICA
سال: 2001
ISSN: 0044-5991,1347-5800
DOI: 10.1267/ahc.34.349